QuadraSphere® Microspheres (US Only)

Predictable, Flow-Directed Targeting

QuadraSphere® Microspheres are calibrated, hydrophilic and compress up to 80% to facilitate smooth microcatheter delivery. Once through the microcatheter, they rebound to their stated spherical shape with a consistent cross-sectional diameter for predictable, flow-directed targeting. 

Targeted Occlusion

The in vivo median diameter of occluded arteries is significantly different between sizes of QuadraSphere Microspheres,* providing targeted occlusion.

QuadraSphere Q2 Microspheres demonstrate a median occlusion of 78 µm, a statistically significant difference compared to larger sizes of QuadraSphere.

*Swine liver embolization model study performed for Merit Medical. QuadraSphere Microspheres prepared in 50/50 mixture of saline/contrast.

Angiographies of hypervascularized tumor pre- and post-embolization illustrate the ability of QuadraSphere Microspheres to perform a targeted embolization.

Experience the Power of Conformability

QuadraSphere Microspheres are soft and easily conform to the vessel lumen for complete occlusion:

• Decreasing the risk of vessel recanalization¹
• Enabling greater tumor necrosis^2,3
• Providing optimal contact between the vessel wall and microsphere surface^1,4
• Enhancing the embolic effect, reducing the amount of product needed to reach embolization endpoint¹

 Established

QuadraSphere Microspheres are a recognized and accepted platform for targeted liver embolization. QuadraSphere Microspheres are indicated for:

• Hepatoma
• Arteriovenous Malformations (AVM)
• Hypervascular Tumors (HVT)

Super-Absorbent Polymer

Referred to as super-absorbent polymer (SAP) microspheres, QuadraSphere Microspheres are packaged dry, but once exposed to aqueous-based media, they swell to approximately 4x the size printed on the product label.

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References

1. Bilbao JI, de Luis E, Garcia de Jalón JA, et al. Comparative study of four different spherical embolic particles in an animal model: a morphologic and histologic evaluation. J Vasc Interv Radiol 2008 Nov;19(11):1625-38.
2. Lee KH, Liapi E, Vossen JA, et al. Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy. J Vasc Interv Radiol 2008 Oct;19(10);1490-6.
3. Wáng YXJ, De Baere, Idée JM, et al. Transcatheter embolization therapy in liver cancer: an update of clinical evidences. Chin J Cancer Res 2015;27(2):96-121
4. Van Malenstein H, Maleux G, Vandecaveye V, et al. A randomized phase II study of drug-eluting beads versus transarterial chemoembolization for unresectable hepatocellular carcinoma. Onkologie 2011;34(7):368-76.