QuadraSphere® Microspheres (US Only)

Predictable, Flow-Directed Targeting

QuadraSphere® Microspheres are calibrated, hydrophilic and compress up to 80% to facilitate smooth microcatheter delivery. Once through the microcatheter, they rebound to their stated spherical shape with a consistent cross-sectional diameter for predictable, flow-directed targeting. 

Targeted Occlusion

The in vivo median diameter of occluded arteries is significantly different between sizes of QuadraSphere Microspheres,* providing targeted occlusion.

QuadraSphere Q2 Microspheres demonstrate a median occlusion of 78 µm, a statistically significant difference compared to larger sizes of QuadraSphere.

*Swine liver embolization model study performed for Merit Medical. QuadraSphere Microspheres prepared in 50/50 mixture of saline/contrast.

Angiographies of hypervascularized tumor pre- and post-embolization illustrate the ability of QuadraSphere Microspheres to perform a targeted embolization.

Experience the Power of Conformability

QuadraSphere Microspheres are soft and easily conform to the vessel lumen for complete occlusion:

• Decreasing the risk of vessel recanalization¹
• Enabling greater tumor necrosis^2,3
• Providing optimal contact between the vessel wall and microsphere surface^1,4
• Enhancing the embolic effect, reducing the amount of product needed to reach embolization endpoint¹

 Established

QuadraSphere Microspheres are a recognized and accepted platform for targeted liver embolization. QuadraSphere Microspheres are indicated for:

• Hepatoma
• Arteriovenous Malformations (AVM)
• Hypervascular Tumors (HVT)

Super-Absorbent Polymer

Referred to as super-absorbent polymer (SAP) microspheres, QuadraSphere Microspheres are packaged dry, but once exposed to aqueous-based media, they swell to approximately 4x the size printed on the product label.

References

1. Bilbao JI, de Luis E, Garcia de Jalón JA, et al. Comparative study of four different spherical embolic particles in an animal model: a morphologic and histologic evaluation. J Vasc Interv Radiol 2008 Nov;19(11):1625-38.
2. Lee KH, Liapi E, Vossen JA, et al. Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy. J Vasc Interv Radiol 2008 Oct;19(10);1490-6.
3. Wáng YXJ, De Baere, Idée JM, et al. Transcatheter embolization therapy in liver cancer: an update of clinical evidences. Chin J Cancer Res 2015;27(2):96-121
4. Van Malenstein H, Maleux G, Vandecaveye V, et al. A randomized phase II study of drug-eluting beads versus transarterial chemoembolization for unresectable hepatocellular carcinoma. Onkologie 2011;34(7):368-76.

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Catalog Number	Expanded Family Name	Size Range	Expanding Range	Delivery System	Delivery System Size	Color	Carrier Solution	Volume	HCPCS Code
V125QS	QuadraSphere® Microspheres	20-40 µm	80-160 µm	Vial	10 mL	Gray	Dry	25 mg
V225QS	QuadraSphere® Microspheres	30-60 µm	120-240 µm	Vial	10 mL	Orange	Dry	25 mg	No Applicable Code
V325QS	QuadraSphere® Microspheres	50-100 µm	200-400 µm	Vial	10 mL	Light Green	Dry	25 mg	No Applicable Code
V525QS	QuadraSphere® Microspheres	100-150 µm	400-600 µm	Vial	10 mL	Blue	Dry	25 mg	No Applicable Code
V725QS	QuadraSphere® Microspheres	150-200 µm	600-800 µm	Vial	10 mL	Purple	Dry	25 mg	No Applicable Code