Categories
Procedure
What is the C2 CryoBalloon Ablation System?
The C2 CryoBalloon Ablation System delivers precise, controlled cryoablation for endoscopic treatment of Barrett’s esophagus with dysplasia and gastric antral vascular ectasia (GAVE). Standard and pear-shaped catheter designs reach tubular structures, the gastroesophageal junction, and lesions big and small. Physicians can selectively target and ablate diseased tissue and spare healthy tissue, using nitrous oxide (N2O) to cryogenically freeze and cause necrosis to the target tissue for treatment.
Features and Benefits
C2 CryoBalloon 180° Catheter
The 180° catheter effectively treats long-segment Barrett’s esophagus and maintains the flexibility, accuracy, and visibility of our focal catheter.
C2 CryoBalloon Focal Catheter
For precise, targeted, short-segment Barrett’s esophagus, the C2 CryoBalloon treats tissue at a cellular level.
Why Cryoablation?
Cryoablation causes minimal structural damage to the treated tissue, ultimately preserving the collagen matrix structure.4 Cryoablation has a low adverse-event rate, including strictures and bleeding.5 Patients also report significantly less post-procedural pain and need for narcotic medication compared with radiofrequency ablation.5-7
Product Facts
| C2 CRYOBALLOON 180° Catheter |
C2 CRYOBALLOON FOCAL Catheter |
|
|---|---|---|
| Compliant balloon material | ✓ | ✓ |
| Multiple balloon shapes | ✓ | ✓ |
| Maximum treatment length | 3.0 cm | 1.5 cm |
| Minimum treatment length | 0.5 cm | 1.5 cm |
| Designed to specifically treat the gastroesophageal junction | ✓ | ✓ |
| Compatible with a therapeutic scope | ✓ | ✓ |
| Median procedure time (median ablation time) |
14 minutes (5 minutes)8 |
18 minutes (9 minutes)5 |
FAQs
What is the C2 CryoBalloon Ablation System and who makes it? 
The C2 CryoBalloon Ablation System is a Merit Medical product used for the endoscopic treatment of Barrett’s esophagus with dysplasia and GAVE. It delivers precise, controlled cryoablation using N2O to selectively target and ablate diseased tissue while sparing healthy tissue. Two catheter designs are available—the focal catheter for short-segment Barrett’s esophagus and the 180° catheter for long-segment Barrett’s esophagus.
What conditions is the C2 CryoBalloon indicated to treat?
The C2 CryoBalloon Ablation System is indicated for the endoscopic treatment of Barrett’s esophagus with dysplasia, including both low-grade and high-grade dysplasia, and GAVE. Refer to the full Instructions for Use for complete indications, contraindications, warnings, and precautions.
How does cryoablation differ from radiofrequency ablation for Barrett’s esophagus?
Cryoablation causes minimal structural damage to the treated tissue, ultimately preserving the collagen matrix structure,4 and has a low adverse-event rate, including strictures and bleeding.5 Patients also report significantly less post-procedural pain and need for narcotic medication compared with radiofrequency ablation.5-7 A comparative study7 found that cryoablation treatment for Barrett’s esophagus resulted in greater patient-reported reduction of post-treatment analgesic use compared with heat-based radiofrequency ablation treatment.
What catheter designs are available and when is each used?
The C2 CryoBalloon is available in two catheter designs. The focal catheter (available in pear and standard shapes) is designed for precise, targeted treatment of short-segment Barrett’s esophagus. It treats tissue at a cellular level, and the pear-shaped design allows it to reach the gastroesophageal junction and irregular lesions. The 180° catheter, available in standard (FG-1055) and pear (FG-1056) configurations, effectively treats long-segment Barrett’s esophagus while maintaining the flexibility, accuracy, and visibility of the focal catheter.
How do I order the C2 CryoBalloon Ablation System?
Please contact your Merit Medical representative directly.
Who do I contact about reimbursement?
Please contact your Merit Medical representative for reimbursement information.
What if my question wasn’t answered here?
Please contact Merit Medical Customer Service for further assistance.
Documents
Current IFU
C2 CryoBalloon® Ablation System – IFU (English) 
Current Brochures
C2 CryoBalloon® Ablation System – Brochure (English)
C2 CryoBalloon® Ablation System – Full System Brochure (English)
C2 CryoBalloon® Ablation System – Accessories Brochure (English)
C2 CryoBalloon® Ablation System – Quick Reference Guide (English)
Current Patient Guide
C2 CryoBalloon® Ablation System – Patient Guide (English)
Additional Documents
C2 CryoBalloon® Ablation System – Reimbursement Guide (English)
C2 CryoBalloon® Ablation System – Catheters Specifications (English)
C2 CryoBalloon® Ablation System – Reprocessing Instructions (English)
The Instructions for Use (IFU) provided on this page are for general information purposes only. Please refer to the IFU provided with the actual product for indications, contraindications, warnings, precautions, and directions for use.
Order Information
| Catalog Number | Description |
|---|---|
| Controller and Foot Pedal | |
| FG-1017 | C2 CryoBalloon Controller |
| FG-1018 | C2 CryoBalloon Foot Pedal |
| Catheters | |
| FG-1028 | C2 CryoBalloon Focal Standard Catheter |
| FG-1024 | C2 CryoBalloon Focal Pear Catheter |
| FG-1055 | C2 CryoBalloon 180° Standard Catheter |
| FG-1056 | C2 CryoBalloon 180° Pear Catheter |
| Accessories | |
| FG-1011 | C2 CryoBalloon SideCar™ |
| FG-1013 | C2 CryoBalloon Cartridge (5 Pack) |
| FG-1040 | C2 CryoBalloon EndoGrip™ (5 Pack) |
| FG-1050 | C2 CryoBalloon NitroClip™ |
| FG-1054 | C2 CryoBalloon Storage Case |
Procedures and Resources
References
1. Munters et al. 2024. Gastrointest Endosc. doi: 10.1016/j.gie.2024.04.2319.
2. Frederiks et al. 2023. Gastrointest Endosc. doi: 10.1016/j.gie.2023.04.1508.
3. Dbouk et al. 2022. Tech Innov Gastroint Endosc. doi: 10.1016/j.tige.2021.11.007.
4. Xiao et al. 2026. Cancers. doi: 10.3390/cancers18010059.
5. Canto et al. 2018. Gastrointest Endosc. doi: 10.1016/j.gie.2018.03.024.
6. Schölvinck et al. 2015. Endoscopy. doi: 10.1055/s-0034-1392417.
7. van Munster et al. 2018. Gastrointest Endosc. doi: 10.1016/j.gie.2018.06.015.
8. Fitzgerald. 2026. N Engl J Med. doi: 10.1056/NEJMcp2506887.
Before using any of the products mentioned, refer to Instructions for Use for indications, contraindications, warnings, precautions, and directions for use.
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