QuadraSphere

Learn More About QuadraSphere® Microspheres

Predictable, Flow-Directed Targeting

QuadraSphere® Microspheres are calibrated, hydrophilic and compress up to 80% to facilitate smooth microcatheter delivery. Once through the microcatheter, they rebound to their stated spherical shape with a consistent cross-sectional diameter for predictable, flow-directed targeting. 

Targeted Occlusion

The in vivo median diameter of occluded arteries is significantly different between sizes of QuadraSphere Microspheres,* providing targeted occlusion.

QuadraSphere Q2 Microspheres demonstrate a median occlusion of 78 µm, a statistically significant difference compared to larger sizes of QuadraSphere.

*Swine liver embolization model study performed for Merit Medical. QuadraSphere Microspheres prepared in 50/50 mixture of saline/contrast.

QuadrasphereMicrospheres-embolization

Angiographies of hypervascularized tumor pre- and post-embolization illustrate the ability of QuadraSphere Microspheres to perform a targeted embolization.

Experience the Power of Conformability

QuadraSphere Microspheres are soft and easily conform to the vessel lumen for complete occlusion:

  • Decreasing the risk of vessel recanalization1
  • Enabling greater tumor necrosis2,3
  • Providing optimal contact between the vessel wall and microsphere surface1,4
  • Enhancing the embolic effect, reducing the amount of product needed to reach embolization endpoint1

 Established

QuadraSphere Microspheres are a recognized and accepted platform for targeted liver embolization. QuadraSphere Microspheres are indicated for:

  • Hepatoma
  • Arteriovenous Malformations (AVM)
  • Hypervascular Tumors (HVT)

Super-Absorbent Polymer

Referred to as super-absorbent polymer (SAP) microspheres, QuadraSphere Microspheres are packaged dry, but once exposed to aqueous-based media, they swell to approximately 4x the size printed on the product label.

References

  1. Bilbao JI, de Luis E, Garcia de Jalón JA, et al. Comparative study of four different spherical embolic particles in an animal model: a morphologic and histologic evaluation. J Vasc Interv Radiol 2008 Nov;19(11):1625-38.
  2. Lee KH, Liapi E, Vossen JA, et al. Distribution of iron oxide-containing Embosphere particles after transcatheter arterial embolization in an animal model of liver cancer: evaluation with MR imaging and implication for therapy. J Vasc Interv Radiol 2008 Oct;19(10);1490-6.
  3. Wáng YXJ, De Baere, Idée JM, et al. Transcatheter embolization therapy in liver cancer: an update of clinical evidences. Chin J Cancer Res 2015;27(2):96-121
  4. Van Malenstein H, Maleux G, Vandecaveye V, et al. A randomized phase II study of drug-eluting beads versus transarterial chemoembolization for unresectable hepatocellular carcinoma. Onkologie 2011;34(7):368-76.

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Catalog NumberExpanded Family NameSize RangeExpanding RangeDelivery SystemDelivery System SizeColorCarrier SolutionVolumeHCPCS Code
V125QSQuadraSphere® Microspheres20-40 µm80-160 µmVial10 mLGrayDry25 mg
V225QSQuadraSphere® Microspheres30-60 µm120-240 µmVial10 mLOrangeDry25 mgNo Applicable Code
V325QSQuadraSphere® Microspheres50-100 µm200-400 µmVial10 mLLight GreenDry25 mgNo Applicable Code
V525QSQuadraSphere® Microspheres100-150 µm400-600 µmVial10 mLBlueDry25 mgNo Applicable Code
V725QSQuadraSphere® Microspheres150-200 µm600-800 µmVial10 mLPurpleDry25 mgNo Applicable Code